Exploring the Nexus between Young Marriage and Cervical Cancer Incidence
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Abstract
Cervical cancer remains a significant global health challenge, disproportionately affecting women in low- and middle-income countries. While age at marriage has emerged as a potential risk factor for cervical cancer, the relationship between young marriage and disease incidence remains complex and poorly understood. This research study aimed to systematically investigate the association between young marriage and cervical cancer incidence, exploring mediating factors, temporal relationships, and disease progression pathways. Utilizing a retrospective cohort study design, data were collected from diverse populations of women of reproductive age, encompassing both urban and rural settings. Comprehensive demographic, clinical, and socio-economic information were retrieved from electronic health records, population registries, and national databases. Statistical analyses, including bivariate, multivariate, and longitudinal approaches, were employed to examine the association between age at marriage and cervical cancer risk, while controlling for potential confounders and mediating factors. The findings of the study revealed a significant association between young marriage and increased cervical cancer incidence, with women who married at younger ages exhibiting a higher risk of disease compared to those who married later in life. Socio-economic disparities, limited access to healthcare services, and risky sexual behaviors were identified as mediating factors influencing the relationship between age at marriage and cervical cancer risk. Longitudinal analyses indicated accelerated disease progression and earlier onset of cervical cancer among women who married at younger ages, highlighting the importance of early intervention and targeted screening programs for at-risk populations.
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Ayka, S. T. (2020). Determinants of screening practice for cervical cancer among women in Addis Ababa, Ethiopia. University of South Africa.
Balasubramaniam, S. D., Balakrishnan, V., Oon, C. E., & Kaur, G. (2019). Key molecular events in cervical cancer development. Medicina, 55(7), 384.
Bayrami, R., Taghipour, A., & Ebrahimipour, H. (2015). Personal and socio-cultural barriers to cervical cancer screening in Iran, patient and provider perceptions: a qualitative study. Asian Pacific Journal of Cancer Prevention, 16(9), 3729–3734.
Bowyer, H. L., Dodd, R. H., Marlow, L. A. V, & Waller, J. (2014). Association between human papillomavirus vaccine status and other cervical cancer risk factors. Vaccine, 32(34), 4310–4316.
Buskwofie, A., David-West, G., & Clare, C. A. (2020). A review of cervical cancer: incidence and disparities. Journal of the National Medical Association, 112(2), 229–232.
Chambuso, R. S. (2019). Human Immunodeficiency Virus/Human Papillomavirus co-infection and host molecular genetics of cervical carcinoma.
Chan, C. W. H., Yang, S., Gu, C., Wang, X., & Tao, L. (2015). Perception of cervical cancer risk and screening behavior: a literature review. International Journal of Nursing Knowledge, 26(1), 2–18.
Chen, H.-C., Schiffman, M., Lin, C.-Y., Pan, M.-H., You, S.-L., Chuang, L.-C., Hsieh, C.-Y., Liaw, K.-L., Hsing, A. W., & Chen, C.-J. (2011). Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. Journal of the National Cancer Institute, 103(18), 1387–1396.
Delprato, M., Akyeampong, K., Sabates, R., & Hernandez-Fernandez, J. (2015). On the impact of early marriage on schooling outcomes in Sub-Saharan Africa and South West Asia. International Journal of Educational Development, 44, 42–55.
Drain, P. K., Holmes, K. K., Hughes, J. P., & Koutsky, L. A. (2002). Determinants of cervical cancer rates in developing countries. International Journal of Cancer, 100(2), 199–205.
Haverkos, H., Rohrer, M., & Pickworth, W. (2000). The cause of invasive cervical cancer could be multifactorial. Biomedicine & Pharmacotherapy, 54(1), 54–59.
Huang, Z., Zheng, Y., Wen, W., Wu, C., Bao, P., Wang, C., Zhong, W., Gao, Y.-T., Jin, F., & Xiang, Y.-B. (2016). Incidence and mortality of gynaecological cancers: Secular trends in urban Shanghai, China over 40 years. European Journal of Cancer, 63, 1–10.
Juneja, A., Sehgal, A., Mitra, A. B., & Pandey, A. (2003). A survey on risk factors associated with cervical cancer. Indian Journal of Cancer, 40(1), 15–22.
Kagika, R. W. K. (2018). A Study Of Factors Influencing Access And Utilization Of Cervical Cancer Screening Services Among Women Of Reproductive Age In Murang’A County, Kenya. University of Nairobi.
Kjær, S. K., Van Den Brule, A. J. C., Bock, J. E., Poll, P. A., Engholm, G., Sherman, M. E., Walboomers, J. M. M., & Meijer, C. J. L. M. (1996). Human papillomavirus—the most significant risk determinant of cervical intraepithelial neoplasia. International Journal of Cancer, 65(5), 601–606.
Krings, A., Dunyo, P., Pesic, A., Tetteh, S., Hansen, B., Gedzah, I., Wormenor, C. M., Amuah, J. E., Behnke, A.-L., & Höfler, D. (2019). Characterization of Human Papillomavirus prevalence and risk factors to guide cervical cancer screening in the North Tongu District, Ghana. PLoS One, 14(6), e0218762.
Li, X., Hu, S. Y., He, Y., Hernandez Donoso, L., Qu, K. Q., Van Kriekinge, G., & Zhao, F. H. (2018). Systematic literature review of risk factors for cervical cancer in the Chinese population. Women’s Health, 14, 1745506518816599.
López‐López, J. A., Page, M. J., Lipsey, M. W., & Higgins, J. P. T. (2018). Dealing with effect size multiplicity in systematic reviews and meta‐analyses. Research Synthesis Methods, 9(3), 336–351.
Louie, K. S., De Sanjose, S., Diaz, M., Castellsagué, X., Herrero, R., Meijer, C. J., Shah, K., Franceschi, S., Muñoz, N., & Bosch, F. X. (2009). Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries. British Journal of Cancer, 100(7), 1191–1197.
Mannino, D. M., & Buist, A. S. (2007). Global burden of COPD: risk factors, prevalence, and future trends. The Lancet, 370(9589), 765–773.
Oppenheimer, V. K. (1988). A theory of marriage timing. American Journal of Sociology, 94(3), 563–591.
Rosenthal, R. (1986). Meta-Analytic Procedures for Social Science Research Sage Publications: Beverly Hills, 1984, 148 pp. Educational Researcher, 15(8), 18–20.
Rotkin, I. D. (1973). A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Research, 33(6), 1353–1367.
Sammarco, M. L., Tamburro, M., Pulliero, A., Izzotti, A., & Ripabelli, G. (2020). Human papillomavirus infections, cervical cancer and MicroRNAs: an overview and implications for public health. MicroRNA, 9(3), 174–186.
Small Jr, W., Bacon, M. A., Bajaj, A., Chuang, L. T., Fisher, B. J., Harkenrider, M. M., Jhingran, A., Kitchener, H. C., Mileshkin, L. R., & Viswanathan, A. N. (2017). Cervical cancer: a global health crisis. Cancer, 123(13), 2404–2412.
Soman, T. P. A. (2017). Social, genetic and behavioural risk factors of Head and Neck Cancers-Elucidating causal pathways. McGill University (Canada).
Thananowan, N., & Vongsirimas, N. (2016). Factors mediating the relationship between intimate partner violence and cervical cancer among Thai women. Journal of Interpersonal Violence, 31(4), 715–731.
Thongsak, N., Chitapanarux, I., Suprasert, P., Prasitwattanaseree, S., Bunyatisai, W., Sripan, P., & Traisathit, P. (2016). Spatial and temporal analyses of cervical cancer patients in upper Northern Thailand. Asian Pacific Journal of Cancer Prevention: APJCP, 17(11), 5011.
Wunsch, G., Russo, F., & Mouchart, M. (2010). Do we necessarily need longitudinal data to infer causal relations? Bulletin of Sociological Methodology/Bulletin de Méthodologie Sociologique, 106(1), 5–18.
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