Effect of gambir catechins on cholesterol levels of mice hypercholerolemia
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Published:
May 2, 2023
Keywords:
Gambir, Catechin, Cholesterol
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Abstract
Hypercholesterolemia is a condition characterized by increased level of cholesterol in the blood exceeding the normal threshold. Gambir (Uncari gambir Roxb.) contains chemical compounds, namely flavonoid, specifically catechin. Catechin in gambir has the potential to increase fat metabolism therefore it has the potential to reduce cholesterol level in the body of mice. The purpose of this study is to determine the effect of gambir catechin on cholesterol levels in hypercholesterolemic mice. The study is an experiment with a Completely Randomized Design (CRD) with two control groups and three treatment groups those are K negative was not given treatment, K positive was induced by simvastatin after induction of a high-fat diet, P1, P2 and P3 were induced by catechin with different concentrations of 50%, 80% and 90% after being induced by a high-fat diet. Cholesterol level was checked with Easy touch GCU. Data was analyzed by One Way of Variance (ANOVA) followed by 5%-degree DMRT test. The result shows that gambir catechin has the effect (p<0.05) on reducing cholesterol level in hypercholesterolemic patients. The most effective using of catechin with the level of concentration of catechin is at 90%.
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How to Cite
Anggaraini, M., Yuniarti, E., M, D., & Ramadhani, S. (2023). Effect of gambir catechins on cholesterol levels of mice hypercholerolemia. International Journal on Health and Medical Sciences, 1(2), 91–96. Retrieved from https://journals.iarn.or.id/index.php/HealMed/article/view/73
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Waspadji, S., S. K. and O. (2007). Pedoman Diet Diabetes Mellitus; Sebagai Panduan Bagi Ahli Gizi, Dokter, Pelajar, dan Tenaga Kesehatan Lainnya. Faculty of Medicine, University of Indonesia.
Wibowo, T. (2009). Pengaruh seduhan kelopak bunga rosela (Hibiscus sabdariffa) terhadap kadar trigliserida darah pada tikus putih (Rattus norvegicus) [Thesis]. Universitas Sebelas Maret.
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Yeni, G., Sa’id, E. G., Syamsu, K., & Mardliyati, E. (2014). Penentuan kondisi terbaik ekstraksi antioksidan dari gambir menggunakan metode permukaan respon. Jurnal Litbang Industri, 4(1), 39–48.
Yeni, G., Syamsu, K., Mardliyati, E., & Muchtar, H. (2017). Penentuan teknologi proses pembuatan gambir murni dan katekin terstandar dari gambir asalan. Jurnal Litbang Industri, 7(1), 1–10.
Yeni, G., Syamsu, K., Suparno, O., Mardliyati, E., & Muchtar, H. (2014). Repeated extraction process of raw gambiers (Uncaria gambier Robx.) for the catechin production as an antioxidant. Int. J. Appl. Eng. Res, 9(24), 24565–24578.
Amalia, A. (2009). Uji Efek Imunomodulator Ekstrak Etanol Gambir (Uncaria gambir R.) terhadap Aktivitas dan Kapasitas Fagositosis Sel Makrofag Peritonium Mencit secara In Vivo. Skripsi Program Studi Farmasi Fakultas Kedokteran Dan Ilmu Kesehatan UIN. Jakarta.
Anggraini, T., Tai, A., Yoshino, T., & Itani, T. (2011). Antioxidative activity and catechin content of four kinds of Uncaria gambir extracts from West Sumatra, Indonesia. African Journal of Biochemistry Research, 5(1), 33–38.
Dhalimi, A. (2006). Permasalahan gambir (Uncaria gambir L.) di Sumatera Barat dan alternatif pemecahannya. Perspektif: Review Penelitian Tanaman Industri, 5(1), 46–59.
Diaz, M. N., Frei, B., Vita, J. A., & Keaney Jr, J. F. (1997). Antioxidants and atherosclerotic heart disease. New England Journal of Medicine, 337(6), 408–416.
Ekawati. (2007). Effect of Black Tea (Camellia sinensis (L.) O.K.) on Coronary Artery Wall Thickness in White Rats (Rattus norvegicus) Given a High Fat Diet. Fakultas Kedokteran Universitas Gadjah Mada.
Ermiati. (2004). Budidaya, Pengolahan Produk dan Kelayakan Usaha Tani Gambir (Uncaria gambir Roxb.) di Kabupaten 50 Kota. TRO Bulletin.
Fajrin, F. A. (2010). Black glutinous ethanol extract activity to lower cholesterol levels. Jurnal Farmasi Indonesia, 5(2), 63–69.
Guyton. A. C and J. E. Hall. (2006). Textbook of Medical Physiology 11th Edition. EGC.Textbook of Medical Physiology 11th Edition. EGC.
Hadad, E. et al. (2007). Teknologi Budidaya dan Pengolahan Produk Gambir.Teknologi Budidaya dan Pengolahan Produk Gambir.
Heitzman, M. E., Neto, C. C., Winiarz, E., Vaisberg, A. J., & Hammond, G. B. (2005). Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry, 66(1), 5–29.
Langseth, L. (1995). Oxidants, antioxidants, and disease prevention. ILSI Europe Brussels’s, Belgium.
Latifat, L. (2015). Identifikasi golongan senyawa flavonoid dan uji aktivitas antioksidan pada ekstrak rimpang kencur Kaemferia galanga L. dengan metode dpph (1, 1-difenil-2-pikrilhidrazil) [Doctoral dissertation]. Universitas Islam Negeri Maulana Malik Ibrahim.
Lewis, G. F., & Rader, D. J. (2005). New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circulation Research, 96(12), 1221–1232.
Mu’nisa, A., Asmawati, A., Farida, A., & Fressy, F. A. (2018). Effect of Powder Leaf Breadfruit Disposals (Arthocarpus Altilis) in Oil Mandar District and Polman Against Cholesterol and Glucose Mice (Mus Musculus). Journal of Physics: Conference Series, 954(1), 012012.
Nazir, N. (2000). Gambir, budidaya, pengolahan, dan prospek diversifikasinya. Yayasan Hutanku. Padang, 138.
Rauf, A., & Siregar, A. Z. (2015). The condition of Uncaria gambir Roxb. as one of important medicinal plants in North Sumatra Indonesia. Procedia Chemistry, 14, 3–10.
Santoso, P. (2012). Khasiat Getah Gambir (Uncaria gambir) sebagai antihiperglikemik dan penstabil nilai darah pada hewan uji mencit putih (Mus musculus). Scientific Articles.
Sari, G. P. (2010). Uji efek analgetik dan antiinflamasi ekstrak kering air gambir secara in vivo.
Sari, H. (2010). Uji Efek Hipoglikemik Ekstrak Etanol Gambir (Uncaria gambir R.) pada Tikus Putih Jantan dengan Metode Induksi Aloksan dan Toleransi Glukosa. Skripsi.
Sitompul, B. (2003). Antioxidants and Atherosclerosis. Medica Hospitalia Article, 6(29), 373–377.
Suyatna, F. D., & Handoko, T. (2007). Hipolipidemik dalam farmakologi dan terapi edisi 5. Jakarta: Departemen Farmakologi Dan Terapeutik FK UI.
Usoh, I. F., Akpan, E. J., Etim, E. O., & Farombi, E. O. (2005). Antioxidant actions of dried flower extracts of Hibiscus sabdariffa L. on sodium arsenite-induced oxidative stress in rats. Pakistan Journal of Nutrition, 4(3), 135–141.
Waspadji, S., S. K. and O. (2007). Pedoman Diet Diabetes Mellitus; Sebagai Panduan Bagi Ahli Gizi, Dokter, Pelajar, dan Tenaga Kesehatan Lainnya. Faculty of Medicine, University of Indonesia.
Wibowo, T. (2009). Pengaruh seduhan kelopak bunga rosela (Hibiscus sabdariffa) terhadap kadar trigliserida darah pada tikus putih (Rattus norvegicus) [Thesis]. Universitas Sebelas Maret.
Winarsi, H. (2007). Antioksidan Alami dan Radikal Bebas (Potensi dan Penerapannya dalam Kesehatan). Canisius.
Yeni, G., Sa’id, E. G., Syamsu, K., & Mardliyati, E. (2014). Penentuan kondisi terbaik ekstraksi antioksidan dari gambir menggunakan metode permukaan respon. Jurnal Litbang Industri, 4(1), 39–48.
Yeni, G., Syamsu, K., Mardliyati, E., & Muchtar, H. (2017). Penentuan teknologi proses pembuatan gambir murni dan katekin terstandar dari gambir asalan. Jurnal Litbang Industri, 7(1), 1–10.
Yeni, G., Syamsu, K., Suparno, O., Mardliyati, E., & Muchtar, H. (2014). Repeated extraction process of raw gambiers (Uncaria gambier Robx.) for the catechin production as an antioxidant. Int. J. Appl. Eng. Res, 9(24), 24565–24578.
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