Evaluation of Antibiotic Use in Dengue Fever Patients Using the ATC/DDD Method at HKBP Hospital
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
Infectious diseases are diseases caused by the entry and growth of microorganisms, one of which is pathogenic bacteria (Novard et al., 2019). High use of antibiotics for infectious diseases increases the risk of irrational antibiotic use which can result in the therapeutic goal not being achieved. This study aims to determine based on patient characteristics, the profile of antibiotic use in hospitalized patients at RSU. HKBP Balige and the quantity of antibiotic use in DDD units. This study is observational (non-experimental) which was conducted retrospectively using data obtained from the Hospital Information System (SIRS) for the period January-April 2024 in the form of drug names, dosage forms, dosage strengths, quantity of use, number of hospitalized patients per month, length of hospitalization. Data analysis in this study used the quantitative Anatomical Therapeutic Chemical (ATC) / Defined Daily Dose (DDD) and Drug Utilization 90% (DU90%) methods. The results of the study showed that there were 2 types of antibiotics used in dengue fever patients during 2024 with an average total usage value of 280.07 DDD/100 HR. The most widely used types of antibiotics were cefixime (66.70%) and cefotaxime (33.30%), and the most common route of antibiotic administration was intravenous, and the most frequent duration of antibiotic therapy was <3 days (85.71%).
##plugins.themes.bootstrap3.article.details##
Bhalerao, U., Preethi, L., Bhukya, P. L., & Mhaske, S. T. (2023). Dengue Haemorrhagic Fever: A Resurgent Arbovirosis in Humans. In Emerging Human Viral Diseases, Volume I: Respiratory and Haemorrhagic Fever (pp. 315–343). Springer.
Bhatt, L., & Pandey, D. (2023). Review on Dengue Fever. International Journal of Multidisciplinary Educational Research, 12(7), 74–86.
Czapla, M., Juárez-Vela, R., Łokieć, K., Wleklik, M., Karniej, P., & Smereka, J. (2022). The association between nutritional status and length of hospital stay among patients with hypertension. International Journal of Environmental Research and Public Health, 19(10), 5827.
Dehghani, R., & Kassiri, H. (2021). A review on epidemiology of dengue viral infection as an emerging disease. Research Journal of Pharmacy and Technology, 14(4), 2296–2301.
Garbe, E., Suissa, S., & Douros, A. (2023). Pharmacoepidemiology. In Handbook of epidemiology (pp. 1–55). Springer.
Gupta, N., Ish, P., Kumar, R., Dev, N., Yadav, S. R., Malhotra, N., Agrawal, S., Gaind, R., Sachdeva, H., & group, S. H. C. 2019 working. (2020). Evaluation of the clinical profile, laboratory parameters and outcome of two hundred COVID-19 patients from a tertiary centre in India. Monaldi Archives for Chest Disease, 90(4).
Krishna, G., Sreedevi, S., & Thrimothi, D. (2024). Dengue Virus Infection: Etiology, Epidemiology, Pathogenesis, Diagnosis, and Prevention. In Viral Infectious Diseases Annual Volume 2024. IntechOpen.
Leowattana, W., & Leowattana, T. (2021). Dengue hemorrhagic fever and the liver. World Journal of Hepatology, 13(12), 1968.
Mohsina, F. P., Faheem, I. P., Mohammad, M., Tabassum, S., Tarkash, S., Shah, I., & Patil, A. (2022). Prevalence, pathogenesis and identification of clinical risk factors associated with dengue virus (DENV). Indo Global Journal of Pharmaceutical Sciences, 12, 189–196.
Murugesan, A., & Manoharan, M. (2020). Dengue virus. In Emerging and reemerging viral pathogens (pp. 281–359). Elsevier.
Parveen, S., Riaz, Z., Saeed, S., Ishaque, U., Sultana, M., Faiz, Z., Shafqat, Z., Shabbir, S., Ashraf, S., & Marium, A. (2023). Dengue hemorrhagic fever: a growing global menace. Journal of Water and Health, 21(11), 1632–1650.
Sudarmaja, I. M., Swastika, I. K., Diarthini, L. P. E., Prasetya, I. P. D., & Wirawan, I. M. A. (2022). Dengue virus transovarial transmission detection in Aedes aegypti from dengue hemorrhagic fever patients’ residences in Denpasar, Bali. Veterinary World, 15(4), 1149.
Suyal, D. C., Karnwal, A., Kumar, V., & Zhong, Y. (2024). Achhada Ujalkaur Avatsingh1, Shilpa Sharma1, Shilippreet Kour1, Yukta Arora1, Sheetal Sharma1, Divya Joshi2, Prem Prashant Chaudhary3, Kahkashan Perveen4, Mohab Amin Kamal5 and Nasib Singh 1. Hazardous Pollutants in Agricultural Soil and Environment, 37.
Wang, W.-H., Urbina, A. N., Chang, M. R., Assavalapsakul, W., Lu, P.-L., Chen, Y.-H., & Wang, S.-F. (2020). Dengue hemorrhagic fever–A systemic literature review of current perspectives on pathogenesis, prevention and control. Journal of Microbiology, Immunology and Infection, 53(6), 963–978.
Zerfu, B., Kassa, T., & Legesse, M. (2023). Epidemiology, biology, pathogenesis, clinical manifestations, and diagnosis of dengue virus infection, and its trend in Ethiopia: a comprehensive literature review. Tropical Medicine and Health, 51(1), 11.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.