Effect of Vitamin D Supplementation on Bone Fracture Healing: Impact on Healing Rates, Recovery Time, and Functional Recovery
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Published:
Dec 30, 2024
Keywords:
Vitamin D supplementation, Bone fracture healing, Recovery time, Functional recovery, Osteoporosis
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Articles
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Abstract
This study examines the effect of vitamin D supplementation on bone fracture healing, focusing on its ability to improve healing rates, reduce time to union, and enhance functional recovery. A deficiency in vitamin D is linked to slower bone healing and higher risk of complications, particularly in individuals with limited sun exposure or osteoporosis. The research demonstrates that vitamin D supplementation can significantly accelerate bone healing, making it a valuable intervention in fracture care. The findings suggest that incorporating vitamin D into clinical guidelines could optimize patient outcomes, particularly in vulnerable populations such as the elderly. However, further research is needed to establish the optimal dosage, duration, and long-term effects of vitamin D supplementation. This approach has the potential to reduce healthcare costs by minimizing complications and improving overall fracture recovery, making it a cost-effective and accessible solution in clinical settings. The study highlights the importance of addressing vitamin D deficiency in fracture patients and the potential for improved patient quality of life and bone health.
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How to Cite
Beatarisa, C., & Qaissara, E. (2024). Effect of Vitamin D Supplementation on Bone Fracture Healing: Impact on Healing Rates, Recovery Time, and Functional Recovery. International Journal on Health and Medical Sciences, 3(1), 40–46. Retrieved from https://journals.iarn.or.id/index.php/HealMed/article/view/386
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Fischer, V., Haffner-Luntzer, M., Amling, M., & Ignatius, A. (2018). Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. Eur Cell Mater, 35(35), 365–385.
Gorter, E. A., Hamdy, N. A. T., Appelman-Dijkstra, N. M., & Schipper, I. B. (2014). The role of vitamin D in human fracture healing: a systematic review of the literature. Bone, 64, 288–297.
Grossman, D. C., Curry, S. J., Owens, D. K., Barry, M. J., Caughey, A. B., Davidson, K. W., Doubeni, C. A., Epling, J. W., Kemper, A. R., & Krist, A. H. (2018). Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: US Preventive Services Task Force recommendation statement. Jama, 319(15), 1592–1599.
Grossman, J., & Mackenzie, F. J. (2005). The randomized controlled trial: gold standard, or merely standard? Perspectives in Biology and Medicine, 48(4), 516–534.
Hao, Y., Wang, X., Wang, L., Lu, Y., Mao, Z., Ge, S., & Dai, K. (2015). Zoledronic acid suppresses callus remodeling but enhances callus strength in an osteoporotic rat model of fracture healing. Bone, 81, 702–711.
Hegde, V., Jo, J. E., Andreopoulou, P., & Lane, J. M. (2016). Effect of osteoporosis medications on fracture healing. Osteoporosis International, 27, 861–871.
Hernigou, P., Sitbon, J., Dubory, A., & Auregan, J. C. (2019). Vitamin D history part III: the “modern times”—new questions for orthopaedic practice: deficiency, cell therapy, osteomalacia, fractures, supplementation, infections. International Orthopaedics, 43, 1755–1771.
Malafarina, V., Reginster, J.-Y., Cabrerizo, S., Bruyère, O., Kanis, J. A., Martinez, J. A., & Zulet, M. A. (2018). Nutritional status and nutritional treatment are related to outcomes and mortality in older adults with hip fracture. Nutrients, 10(5), 555.
Maraka, S., & Kennel, K. A. (2015). Bisphosphonates for the prevention and treatment of osteoporosis. Bmj, 351.
Marsell, R., & Einhorn, T. A. (2011). The biology of fracture healing. Injury, 42(6), 551–555.
Mirhosseini, N., Rainsbury, J., & Kimball, S. M. (2018). Vitamin D supplementation, serum 25 (OH) D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis. Frontiers in Cardiovascular Medicine, 5, 87.
Morgan, E. F., Mason, Z. D., Chien, K. B., Pfeiffer, A. J., Barnes, G. L., Einhorn, T. A., & Gerstenfeld, L. C. (2009). Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function. Bone, 44(2), 335–344.
Pisani, P., Renna, M. D., Conversano, F., Casciaro, E., Di Paola, M., Quarta, E., Muratore, M., & Casciaro, S. (2016). Major osteoporotic fragility fractures: Risk factor updates and societal impact. World Journal of Orthopedics, 7(3), 171.
Pludowski, P., Holick, M. F., Grant, W. B., Konstantynowicz, J., Mascarenhas, M. R., Haq, A., Povoroznyuk, V., Balatska, N., Barbosa, A. P., & Karonova, T. (2018). Vitamin D supplementation guidelines. The Journal of Steroid Biochemistry and Molecular Biology, 175, 125–135.
Ravisankar, P., Reddy, A. A., Nagalakshmi, B., Koushik, O. S., Kumar, B. V., & Anvith, P. S. (2015). The comprehensive review on fat soluble vitamins. IOSR Journal of Pharmacy, 5(11), 12–28.
Roberts, J. L., & Drissi, H. (2020). Advances and promises of nutritional influences on natural bone repair. Journal of Orthopaedic Research®, 38(4), 695–707.
Roth, D. E., Abrams, S. A., Aloia, J., Bergeron, G., Bourassa, M. W., Brown, K. H., Calvo, M. S., Cashman, K. D., Combs, G., & De‐Regil, L. M. (2018). Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐and middle‐income countries. Wiley Online Library.
Schlickewei, C. W., Kleinertz, H., Thiesen, D. M., Mader, K., Priemel, M., Frosch, K.-H., & Keller, J. (2019). Current and future concepts for the treatment of impaired fracture healing. International Journal of Molecular Sciences, 20(22), 5805.
Serna, J., & Bergwitz, C. (2020). Importance of dietary phosphorus for bone metabolism and healthy aging. Nutrients, 12(10), 3001.
Sprague, S., Bhandari, M., Devji, T., Scott, T., Petrisor, B., McKay, P., & Slobogean, G. P. (2016). Prescription of vitamin D to fracture patients: a lack of consensus and evidence. Journal of Orthopaedic Trauma, 30(2), e64–e69.
Takács, I., Tóth, B. E., Szekeres, L., Szabó, B., Bakos, B., & Lakatos, P. (2017). Randomized clinical trial to comparing efficacy of daily, weekly and monthly administration of vitamin D 3. Endocrine, 55, 60–65.
Theodoratou, E., Tzoulaki, I., Zgaga, L., & Ioannidis, J. P. A. (2014). Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. Bmj, 348.
Turner, A. G., Anderson, P. H., & Morris, H. A. (2012). Vitamin D and bone health. Scandinavian Journal of Clinical and Laboratory Investigation, 72(sup243), 65–72.
Bigham‐Sadegh, A., & Oryan, A. (2015). Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures. International Wound Journal, 12(3), 238–247.
Cashman, K. D. (2020). Vitamin D deficiency: defining, prevalence, causes, and strategies of addressing. Calcified Tissue International, 106(1), 14–29.
Einhorn, T. A., & Gerstenfeld, L. C. (2015). Fracture healing: mechanisms and interventions. Nature Reviews Rheumatology, 11(1), 45–54.
Fischer, V., Haffner-Luntzer, M., Amling, M., & Ignatius, A. (2018). Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. Eur Cell Mater, 35(35), 365–385.
Gorter, E. A., Hamdy, N. A. T., Appelman-Dijkstra, N. M., & Schipper, I. B. (2014). The role of vitamin D in human fracture healing: a systematic review of the literature. Bone, 64, 288–297.
Grossman, D. C., Curry, S. J., Owens, D. K., Barry, M. J., Caughey, A. B., Davidson, K. W., Doubeni, C. A., Epling, J. W., Kemper, A. R., & Krist, A. H. (2018). Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: US Preventive Services Task Force recommendation statement. Jama, 319(15), 1592–1599.
Grossman, J., & Mackenzie, F. J. (2005). The randomized controlled trial: gold standard, or merely standard? Perspectives in Biology and Medicine, 48(4), 516–534.
Hao, Y., Wang, X., Wang, L., Lu, Y., Mao, Z., Ge, S., & Dai, K. (2015). Zoledronic acid suppresses callus remodeling but enhances callus strength in an osteoporotic rat model of fracture healing. Bone, 81, 702–711.
Hegde, V., Jo, J. E., Andreopoulou, P., & Lane, J. M. (2016). Effect of osteoporosis medications on fracture healing. Osteoporosis International, 27, 861–871.
Hernigou, P., Sitbon, J., Dubory, A., & Auregan, J. C. (2019). Vitamin D history part III: the “modern times”—new questions for orthopaedic practice: deficiency, cell therapy, osteomalacia, fractures, supplementation, infections. International Orthopaedics, 43, 1755–1771.
Malafarina, V., Reginster, J.-Y., Cabrerizo, S., Bruyère, O., Kanis, J. A., Martinez, J. A., & Zulet, M. A. (2018). Nutritional status and nutritional treatment are related to outcomes and mortality in older adults with hip fracture. Nutrients, 10(5), 555.
Maraka, S., & Kennel, K. A. (2015). Bisphosphonates for the prevention and treatment of osteoporosis. Bmj, 351.
Marsell, R., & Einhorn, T. A. (2011). The biology of fracture healing. Injury, 42(6), 551–555.
Mirhosseini, N., Rainsbury, J., & Kimball, S. M. (2018). Vitamin D supplementation, serum 25 (OH) D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis. Frontiers in Cardiovascular Medicine, 5, 87.
Morgan, E. F., Mason, Z. D., Chien, K. B., Pfeiffer, A. J., Barnes, G. L., Einhorn, T. A., & Gerstenfeld, L. C. (2009). Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function. Bone, 44(2), 335–344.
Pisani, P., Renna, M. D., Conversano, F., Casciaro, E., Di Paola, M., Quarta, E., Muratore, M., & Casciaro, S. (2016). Major osteoporotic fragility fractures: Risk factor updates and societal impact. World Journal of Orthopedics, 7(3), 171.
Pludowski, P., Holick, M. F., Grant, W. B., Konstantynowicz, J., Mascarenhas, M. R., Haq, A., Povoroznyuk, V., Balatska, N., Barbosa, A. P., & Karonova, T. (2018). Vitamin D supplementation guidelines. The Journal of Steroid Biochemistry and Molecular Biology, 175, 125–135.
Ravisankar, P., Reddy, A. A., Nagalakshmi, B., Koushik, O. S., Kumar, B. V., & Anvith, P. S. (2015). The comprehensive review on fat soluble vitamins. IOSR Journal of Pharmacy, 5(11), 12–28.
Roberts, J. L., & Drissi, H. (2020). Advances and promises of nutritional influences on natural bone repair. Journal of Orthopaedic Research®, 38(4), 695–707.
Roth, D. E., Abrams, S. A., Aloia, J., Bergeron, G., Bourassa, M. W., Brown, K. H., Calvo, M. S., Cashman, K. D., Combs, G., & De‐Regil, L. M. (2018). Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐and middle‐income countries. Wiley Online Library.
Schlickewei, C. W., Kleinertz, H., Thiesen, D. M., Mader, K., Priemel, M., Frosch, K.-H., & Keller, J. (2019). Current and future concepts for the treatment of impaired fracture healing. International Journal of Molecular Sciences, 20(22), 5805.
Serna, J., & Bergwitz, C. (2020). Importance of dietary phosphorus for bone metabolism and healthy aging. Nutrients, 12(10), 3001.
Sprague, S., Bhandari, M., Devji, T., Scott, T., Petrisor, B., McKay, P., & Slobogean, G. P. (2016). Prescription of vitamin D to fracture patients: a lack of consensus and evidence. Journal of Orthopaedic Trauma, 30(2), e64–e69.
Takács, I., Tóth, B. E., Szekeres, L., Szabó, B., Bakos, B., & Lakatos, P. (2017). Randomized clinical trial to comparing efficacy of daily, weekly and monthly administration of vitamin D 3. Endocrine, 55, 60–65.
Theodoratou, E., Tzoulaki, I., Zgaga, L., & Ioannidis, J. P. A. (2014). Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. Bmj, 348.
Turner, A. G., Anderson, P. H., & Morris, H. A. (2012). Vitamin D and bone health. Scandinavian Journal of Clinical and Laboratory Investigation, 72(sup243), 65–72.
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