Impact of Nutritional Interventions on Alzheimer's Disease Progression: A Comprehensive Review of Dietary Patterns, Mechanisms, and Clinical Outcomes
##plugins.themes.bootstrap3.article.sidebar##
Published:
Aug 31, 2024
Keywords:
Alzheimer’s Disease (AD), Nutritional Interventions, Dietary Patterns, Cognitive Function, Prevention and Management
Section
Articles
Statistics Article
Article View : 33 Times
##plugins.themes.bootstrap3.article.main##
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, with increasing prevalence worldwide. Recent research has explored the impact of nutritional interventions on AD progression, aiming to identify effective dietary strategies for prevention and management. This research reviews current evidence on various dietary patterns, including the Mediterranean, MIND, and ketogenic diets, and their effects on cognitive function and AD biomarkers. Advances in understanding the mechanisms through which diet influences AD pathology have highlighted the potential for specific nutrients to modulate neuroinflammation, oxidative stress, and amyloid plaque formation. Despite promising findings, challenges such as long-term diet adherence, variability in individual responses, and ethical considerations in human trials persist. The potential benefits of integrating nutritional strategies into AD treatment plans are substantial, offering a complementary approach to pharmacological therapies and contributing to improved patient outcomes and public health. Addressing these challenges through personalized nutrition and continued research could enhance the effectiveness of dietary interventions and provide a pathway toward more effective prevention and management of Alzheimer’s disease.
##plugins.themes.bootstrap3.article.details##
How to Cite
Octavia, I. (2024). Impact of Nutritional Interventions on Alzheimer’s Disease Progression: A Comprehensive Review of Dietary Patterns, Mechanisms, and Clinical Outcomes. International Journal on Health and Medical Sciences, 2(3), 102–113. Retrieved from https://journals.iarn.or.id/index.php/HealMed/article/view/325
References
Abdelhamid, A., Bunn, D., Copley, M., Cowap, V., Dickinson, A., Gray, L., Howe, A., Killett, A., Lee, J., & Li, F. (2016). Effectiveness of interventions to directly support food and drink intake in people with dementia: systematic review and meta-analysis. BMC Geriatrics, 16, 1–18.
Bayer-Carter, J. L., Green, P. S., Montine, T. J., VanFossen, B., Baker, L. D., Watson, G. S., Bonner, L. M., Callaghan, M., Leverenz, J. B., & Walter, B. K. (2011). Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Archives of Neurology, 68(6), 743–752.
Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bezard, E., Pastores, G. M., Rubinsztein, D. C., Nixon, R. A., & Duchen, M. R. (2018). Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nature Reviews Drug Discovery, 17(9), 660–688.
Butterfield, D. A., & Halliwell, B. (2019). Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nature Reviews Neuroscience, 20(3), 148–160.
Chakrabarti, S., Khemka, V. K., Banerjee, A., Chatterjee, G., Ganguly, A., & Biswas, A. (2015). Metabolic risk factors of sporadic Alzheimer’s disease: implications in the pathology, pathogenesis and treatment. Aging and Disease, 6(4), 282.
Chu, C. H. L. (2016). A feasibility study of a multifaceted walking intervention to maintain functional mobility, ADL function, and quality of life among nursing home residents with dementia. University of Toronto (Canada).
Dodd, S., White, I. R., & Williamson, P. (2017). A framework for the design, conduct and interpretation of randomised controlled trials in the presence of treatment changes. Trials, 18, 1–12.
Farlow, M. R., Miller, M. L., & Pejovic, V. (2008). Treatment options in Alzheimer’s disease: maximizing benefit, managing expectations. Dementia and Geriatric Cognitive Disorders, 25(5), 408–422.
Hampel, H., Prvulovic, D., Teipel, S., Jessen, F., Luckhaus, C., Frölich, L., Riepe, M. W., Dodel, R., Leyhe, T., & Bertram, L. (2011). The future of Alzheimer’s disease: the next 10 years. Progress in Neurobiology, 95(4), 718–728.
Holthoff, V. A., Marschner, K., Scharf, M., Steding, J., Meyer, S., Koch, R., & Donix, M. (2015). Effects of physical activity training in patients with Alzheimer’s dementia: results of a pilot RCT study. PloS One, 10(4), e0121478.
Huhn, S., Kharabian Masouleh, S., Stumvoll, M., Villringer, A., & Witte, A. V. (2015). Components of a Mediterranean diet and their impact on cognitive functions in aging. Frontiers in Aging Neuroscience, 7, 132.
Iacono, D., & Feltis, G. C. (2019). Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan. Aging (Albany NY), 11(2), 787.
Ihara, J.-A. R. (2018). Theme: Clinical Trials Methodology.
Irvine, G. B., El-Agnaf, O. M., Shankar, G. M., & Walsh, D. M. (2008). Protein aggregation in the brain: the molecular basis for Alzheimer’s and Parkinson’s diseases. Molecular Medicine, 14, 451–464.
Khan, S. U., Khan, M. U., Riaz, H., Valavoor, S., Zhao, D., Vaughan, L., Okunrintemi, V., Riaz, I. Bin, Khan, M. S., & Kaluski, E. (2019). Effects of nutritional supplements and dietary interventions on cardiovascular outcomes: an umbrella review and evidence map. Annals of Internal Medicine, 171(3), 190–198.
Kirsebom, B.-E., Espenes, R., Hessen, E., Johnsen, S. H., Bråthen, G., Aarsland, D., & Fladby, T. (2017). Screening for Alzheimer’s disease: Cognitive impairment in self-referred and memory clinic-referred patients. Journal of Alzheimer’s Disease, 60(4), 1621–1631.
Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018). Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nature Reviews Neurology, 14(11), 653–666.
Krebs, P., Prochaska, J. O., & Rossi, J. S. (2010). A meta-analysis of computer-tailored interventions for health behavior change. Preventive Medicine, 51(3–4), 214–221.
Mujahid, M. (2016). Alzheimer disease: a review. World J Pharm Pharm Sci, 5(6), 649–666.
Perico, N., Benigni, A., & Remuzzi, G. (2008). Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection. Nature Reviews Drug Discovery, 7(11), 936–953.
Rajmohan, R., & Reddy, P. H. (2017). Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. Journal of Alzheimer’s Disease, 57(4), 975–999.
Rekatsina, M., Paladini, A., Piroli, A., Zis, P., Pergolizzi, J. V, & Varrassi, G. (2020). Pathophysiology and therapeutic perspectives of oxidative stress and neurodegenerative diseases: a narrative review. Advances in Therapy, 37, 113–139.
Seneff, S., Wainwright, G., & Mascitelli, L. (2011). Nutrition and Alzheimer’s disease: the detrimental role of a high carbohydrate diet. European Journal of Internal Medicine, 22(2), 134–140.
Vauzour, D. (2012). Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxidative Medicine and Cellular Longevity, 2012(1), 914273.
Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, L., & Yu, J.-T. (2021). The epidemiology of Alzheimer’s disease modifiable risk factors and prevention. The Journal of Prevention of Alzheimer’s Disease, 8, 313–321.
Zuniga, K., & McAuley, E. (2015). Considerations in selection of diet assessment methods for examining the effect of nutrition on cognition. The Journal of Nutrition, Health and Aging, 19(3), 333–340.
Bayer-Carter, J. L., Green, P. S., Montine, T. J., VanFossen, B., Baker, L. D., Watson, G. S., Bonner, L. M., Callaghan, M., Leverenz, J. B., & Walter, B. K. (2011). Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Archives of Neurology, 68(6), 743–752.
Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bezard, E., Pastores, G. M., Rubinsztein, D. C., Nixon, R. A., & Duchen, M. R. (2018). Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nature Reviews Drug Discovery, 17(9), 660–688.
Butterfield, D. A., & Halliwell, B. (2019). Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nature Reviews Neuroscience, 20(3), 148–160.
Chakrabarti, S., Khemka, V. K., Banerjee, A., Chatterjee, G., Ganguly, A., & Biswas, A. (2015). Metabolic risk factors of sporadic Alzheimer’s disease: implications in the pathology, pathogenesis and treatment. Aging and Disease, 6(4), 282.
Chu, C. H. L. (2016). A feasibility study of a multifaceted walking intervention to maintain functional mobility, ADL function, and quality of life among nursing home residents with dementia. University of Toronto (Canada).
Dodd, S., White, I. R., & Williamson, P. (2017). A framework for the design, conduct and interpretation of randomised controlled trials in the presence of treatment changes. Trials, 18, 1–12.
Farlow, M. R., Miller, M. L., & Pejovic, V. (2008). Treatment options in Alzheimer’s disease: maximizing benefit, managing expectations. Dementia and Geriatric Cognitive Disorders, 25(5), 408–422.
Hampel, H., Prvulovic, D., Teipel, S., Jessen, F., Luckhaus, C., Frölich, L., Riepe, M. W., Dodel, R., Leyhe, T., & Bertram, L. (2011). The future of Alzheimer’s disease: the next 10 years. Progress in Neurobiology, 95(4), 718–728.
Holthoff, V. A., Marschner, K., Scharf, M., Steding, J., Meyer, S., Koch, R., & Donix, M. (2015). Effects of physical activity training in patients with Alzheimer’s dementia: results of a pilot RCT study. PloS One, 10(4), e0121478.
Huhn, S., Kharabian Masouleh, S., Stumvoll, M., Villringer, A., & Witte, A. V. (2015). Components of a Mediterranean diet and their impact on cognitive functions in aging. Frontiers in Aging Neuroscience, 7, 132.
Iacono, D., & Feltis, G. C. (2019). Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan. Aging (Albany NY), 11(2), 787.
Ihara, J.-A. R. (2018). Theme: Clinical Trials Methodology.
Irvine, G. B., El-Agnaf, O. M., Shankar, G. M., & Walsh, D. M. (2008). Protein aggregation in the brain: the molecular basis for Alzheimer’s and Parkinson’s diseases. Molecular Medicine, 14, 451–464.
Khan, S. U., Khan, M. U., Riaz, H., Valavoor, S., Zhao, D., Vaughan, L., Okunrintemi, V., Riaz, I. Bin, Khan, M. S., & Kaluski, E. (2019). Effects of nutritional supplements and dietary interventions on cardiovascular outcomes: an umbrella review and evidence map. Annals of Internal Medicine, 171(3), 190–198.
Kirsebom, B.-E., Espenes, R., Hessen, E., Johnsen, S. H., Bråthen, G., Aarsland, D., & Fladby, T. (2017). Screening for Alzheimer’s disease: Cognitive impairment in self-referred and memory clinic-referred patients. Journal of Alzheimer’s Disease, 60(4), 1621–1631.
Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018). Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nature Reviews Neurology, 14(11), 653–666.
Krebs, P., Prochaska, J. O., & Rossi, J. S. (2010). A meta-analysis of computer-tailored interventions for health behavior change. Preventive Medicine, 51(3–4), 214–221.
Mujahid, M. (2016). Alzheimer disease: a review. World J Pharm Pharm Sci, 5(6), 649–666.
Perico, N., Benigni, A., & Remuzzi, G. (2008). Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection. Nature Reviews Drug Discovery, 7(11), 936–953.
Rajmohan, R., & Reddy, P. H. (2017). Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. Journal of Alzheimer’s Disease, 57(4), 975–999.
Rekatsina, M., Paladini, A., Piroli, A., Zis, P., Pergolizzi, J. V, & Varrassi, G. (2020). Pathophysiology and therapeutic perspectives of oxidative stress and neurodegenerative diseases: a narrative review. Advances in Therapy, 37, 113–139.
Seneff, S., Wainwright, G., & Mascitelli, L. (2011). Nutrition and Alzheimer’s disease: the detrimental role of a high carbohydrate diet. European Journal of Internal Medicine, 22(2), 134–140.
Vauzour, D. (2012). Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxidative Medicine and Cellular Longevity, 2012(1), 914273.
Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, L., & Yu, J.-T. (2021). The epidemiology of Alzheimer’s disease modifiable risk factors and prevention. The Journal of Prevention of Alzheimer’s Disease, 8, 313–321.
Zuniga, K., & McAuley, E. (2015). Considerations in selection of diet assessment methods for examining the effect of nutrition on cognition. The Journal of Nutrition, Health and Aging, 19(3), 333–340.
Copyright and Licensing
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.