Testosterone Undecanoate Hormone Microemulsion Formulation Optimization
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Published:
Dec 1, 2022
Keywords:
Cell stability, Microemulsion, Testosterone undecanoate
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Articles
Statistics Article
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Abstract
Testosterone undecanoate, sometimes known as TU, is a medication that is hydrophobic. A microemulsion is a type of dispersion system that can boost the medications' solubility, especially those that are hydrophobic. In this investigation, the optimization of microemulsion formulations was carried out using a wide variety of surfactants, oils, cosurfactants, and water in their respective proportions. After that, a microemulsion was created with the following components: 30% tween 80 and 10% tween 20 as surfactant components, 24% isopropyl myristate (IPM) and 24% castor oil (CO) as oil phase, 10% n-butanol as a cosurfactant, and 2% water. The oil phase consisted of isopropyl myristate and castor oil. The findings obtained from the TU After being stored at 4o C and 27o C for two months, the examination of the microemulsion revealed that it remained in a stable condition
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How to Cite
Desmond, J., & Bam, R. tu. (2022). Testosterone Undecanoate Hormone Microemulsion Formulation Optimization. International Journal on Health and Medical Sciences, 1(1), 09–17. Retrieved from https://journals.iarn.or.id/index.php/HealMed/article/view/28
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Nandi I, Moh. Bari, Heman Joshi. Study of Isopropyl Myristate Microemulsion System Containing Cyclodextrins to Improve the Solubility of 2 Model Hydrophobic Drugs. AAPS Pharm scitech 2003; 4(1) article 10.
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Block, LH Emulsions and Microemulsions. In Lieberman, HA, Rieger,
MM and Banker GS, eds. Pharmaceutical Dosage Forms : Disperse Systems. Vol. 2. New York: Marcel Dekker. 1989 : 355.
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Jufri, M., Asnimar B, Julia R. Gamexan Formulation in Microemulsion Form.
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Ilyas, Syafruddin. The Effectiveness of Male Hormonal Contraception Using a Combination of Testosterone Undecanoate and Norethisterone Enantat. Sumatran Journal of Biology. Vol. 3. No. 1. 2008. 23-28.
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Leon Lachman, Herbert A. Lieberman and Joseph L. Kanig. Industrial Pharmacy Theory and Practice II. III Edition. Translator Siti Suyatmi. Jakarta: UIPress. 1994; 1076-1079.
Ansel, Howard C. Introduction to Pharmaceutical Dosage Forms. Fourth edition. Jakarta: UIPress. 1989; 143.
Tjay, Tan Hoan and Kirana Rahardja. Essential Medicines. Fifth edition. Jakarta: PT. Gramedia. 2002; 641-642, 645-646.
Sharif, Amir et al. Pharmacology and Therapy. Fourth edition. Jakarta: New Style. 2005; 464.
Wade, Ainley and Paul J. Wellen. Handbook of Pharmaceutical Excipients.
Second edition. London: Pharmaceutical Press. 1994; 83, 243, 375.
Aulthon, Michael E. Pharmaceutics The Science of Dosage Form Design. UK: Elsevier Limited. 2002.
Reynolds, James EF Matindale The Extra Pharmacopeia. 21st edition. London: Pharmaceutical Press. 1982.
Lawrence, M. Jayne and Gareth D. Ress. Microemulsion on-based Media as Novel Drug Delivery Systems. Advanced Drug Delivery Reviews 45 (2000).
Nandi I, Moh. Bari, Heman Joshi. Study of Isopropyl Myristate Microemulsion System Containing Cyclodextrins to Improve the Solubility of 2 Model Hydrophobic Drugs. AAPS Pharm scitech 2003; 4(1) article 10.
Date, Abhijit A and MS Nagarsenker. Parenteral Microemulsion: An over view.
International Journal of Pharmaceutics. 2008.
Ilyas, Syafruddin and Nukman Moeloek. Studies on Testosterone Undecanoate (TU) as a Contraceptive Preparation for Men.
Sinkon, PJ Martin's Physical Pharmacy and Pharmaceutical sciences 5th edition. Elsevier limited. UK: 2002.
Department of Health. Indonesian Pharmacopoeia. IV Edition. Jakarta : Ministry of Health of the Republic of Indonesia. 1995 : 1030
Martin, A., J. Swarbrick and A. Cammarata. Physical Pharmacy 2. Edition III. Jakarta: UIPress. 1993 : 940 – 1010.
Maya, L. Making Microemulsion Preparations from Red Fruit Oil (Pandanus coroideus). Thesis for Bachelor of Pharmacy Program, FMIPA UI. Depok.
Moreno, MA, MP Balesterros, P. Frutos. Lecithin – Based Oil – in – Water Microemulsions for Parenteral Use : Pseudoternary Phase Diagrams, Characterization and Toxicity Studies. International Journal of Pharmaceutics. Vol. 92. 2003. 1428 – 1437.
Rahmawati, J. Preliminary Experiment on Making Microemulsion Preparations with Gamexan as a Drug Model. Thesis for Bachelor of Pharmacy Program, FMIPA UI. Depok.
Sastrohamodjojo, Hardjono. Organic Chemistry. Yogyakarta: Gadjah Mada University Press. 2005 : 104.
Mulja, M. and Suharman. Instrumental Analysis. Surabaya: Airlangga University Press. 1995. 224, 227.
Block, LH Emulsions and Microemulsions. In Lieberman, HA, Rieger,
MM and Banker GS, eds. Pharmaceutical Dosage Forms : Disperse Systems. Vol. 2. New York: Marcel Dekker. 1989 : 355.
Idson, B. Pharmaceutical Emulsions. In: Lieberman, HA, Rieger, MM and Banker GS, eds. Pharmaceutical Dosage Forms : Disperse System. Vol. 1. New York: Marcel Dekker. 1989 : 233, 240.
Jufri, M., Asnimar B, Julia R. Gamexan Formulation in Microemulsion Form.
Pharmaceutical Science Magazine. Vol. I. 2004: 160 – 174.
Ilyas, Syafruddin. The Effectiveness of Male Hormonal Contraception Using a Combination of Testosterone Undecanoate and Norethisterone Enantat. Sumatran Journal of Biology. Vol. 3. No. 1. 2008. 23-28.
Gu, YQ, Jian-sun Tong, Ding-zhi Ma, Xing-hai Wang, Dong Yuan, Wen-hao Tang and William J. Bremner. Male Hormonal Contraception: Effect of Injection of Testosterone Undecanoate and Depot Medroxyprogesterone Acetat at Eight-Week Intervals in Chinese Men. The Journal of Clinical Endocrinology & Metabolism. Vol. 89. No. 5. 2004. 2254-2262.
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